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Mads TimmermannSkincare specialist
Skin science

Oxidative stress

Also called: Oxidation stress, ROS stress

Oxidative stress means reactive oxygen species outpace the skin's antioxidant defences. In skincare, it is usually discussed around UV exposure, pollution, inflammation, and visible ageing.

At a glance

  • UV exposure is one of the big everyday sources of oxidative stress in skin.
  • Antioxidants help neutralise some reactive molecules, but they do not replace sunscreen.
  • Oxidative stress is a process, not a diagnosis you can see in the mirror.
On this page

The short answer

Oxidative stress happens when reactive molecules outpace the skin's antioxidant defences.

In skincare, people usually talk about it around UV exposure, pollution, inflammation, pigmentation, and visible ageing. It is one reason antioxidants sound so appealing.

It is also one reason sunscreen remains boringly important.

What it means in skin

Reactive oxygen species are not automatically evil. The body uses reactive chemistry all the time. The problem is imbalance.

A review on ageing human skin explains that oxidative stress plays a major role in intrinsic and extrinsic skin ageing[1]. Another review describes oxidative stress as a contributor to visible signs of skin ageing and UV-related damage pathways[2].

Plain version: too much reactive chemistry can stress proteins, lipids, DNA, and the systems that keep skin calm.

Where antioxidants fit

Antioxidants help neutralise some reactive molecules.

Useful skincare antioxidants include:

But antioxidants are support, not armour. They do not cancel out sun exposure, and they do not replace SPF.

The practical takeaway

Do not let oxidative stress become another skincare fear phrase.

The calm plan is simple: use sunscreen, avoid unnecessary irritation, consider antioxidants if they fit your routine, and stop chasing every ingredient that promises to "fight free radicals" with heroic music in the background.

Keep reading

Common questions

What causes oxidative stress in skin?

UV exposure, pollution, inflammation, smoking, and normal metabolism can all contribute. UV is the everyday skincare factor we can reduce most directly.

Do antioxidants stop oxidative stress?

They can support the skin's defence against reactive molecules, but they do not make skin invincible and they do not replace sunscreen.

Can I feel oxidative stress?

No. It is a biochemical process, not a sensation. Redness, irritation, dullness, or pigmentation can have many causes.

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Citations

  1. Rinnerthaler M, et al. Oxidative Stress in Aging Human Skin. Biomolecules. 2015;5(2):545-589. - PMC4496685
  2. Petruk G, et al. Focus on the Contribution of Oxidative Stress in Skin Aging. Antioxidants (Basel). 2022;11(6):1121. - PMC9220264